Her film debut was in 1919 in Red Hot Dollars. Her first big success came in 1936 in Gladys George Valiant Is the Word for Carrie. For the role of Carrie Snyder, she was nominated for the Oscar. A year later she starred with Spencer Tracy, the female lead in 1918 - Peace broke out. Probably the biggest success of her career, she celebrated as Iva Archer in 1941 as a partner of Humphrey Bogart in The trace of the falcon. 1951, George made her last film, The Silver City and up to her death in 1954 occurred only in television productions.
Gladys George was temporarily married to the actors Leonard Penn and Ben Erway.